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Nanotechnology provides A variety of chances to add to biology. In this article I'll existing examples exactly where nanofabrication – the chance to make confined constructions with Proportions at will – is made use of to examine the biophysics of single molecules and cells. I will present some examples from our lab:

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, Groningen scientists existing the results of their efforts to produce labs far more sustainable and provide methods for other labs. 

Considering that 2000, Dekker has shifted the primary emphasis of his do the job in the direction of biophysics wherever he studies the Qualities of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of discipline was pushed by his fascination for the exceptional operating of Organic molecular buildings, in addition to through the very long-time period perspective that a lot of intriguing discoveries is often envisioned in this field.[5] Present traces of analysis in his biophysics group are during the parts of:[six]

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and first at any time research of the dynamics DNA supercoils and the invention of supercoil hopping

Experimental stage diagram of negatively supercoiled https://www.ceesdekker.net DNA calculated by magnetic tweezers and fluorescence,

What distinguishes biology from chemistry is always that these components collectively make up a living technique. The secret of explained everyday living, I feel, lies in the interactions, the interplay of Those people molecules. The big problem regarding the origin of everyday living continues to be unanswered. How did we at any time evolve from simple molecules to the extremely intricate units we see right now? We do not know. I need to work on these kinds of major, open queries.’

2011, initially in vitro measurements of transport across a single biomimetic nuclear pore elaborate; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination

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It was for the duration of this era that Dekker performed research on magnetic spin techniques and on sound in superconductors and semiconductors.

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division

2006, first demonstration of molecular sorting within a lab over a chip applying biomotors; discovery of nanobubbles in strong-condition nanopores; and to start with estimate of electrokinetic energy conversion within a nanofluidic channel

Visualization of unstained DNA nanostructures with advanced in-concentrate transmission electron microscopy strategies

Supercoiling-dependent DNA binding: quantitative modeling and apps to bulk and single-molecule experiments